Ancillary equipment helps connect, prepare, clean, and support the core process across pilot and production environments. At TECNIC, this category brings together systems such as mixers, CIP units, and DTS solutions that support preparation, cleaning, and process continuity around the main bioprocess workflow.
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Cassette
We understand the importance of flexibility and efficiency in laboratory processes. That's why our equipment is designed to be compatible with Cassette filters, an advanced solution for a variety of filtration applications. Although we do not manufacture the filters directly, our systems are optimized to take full advantage of the benefits that Cassette filters offer.
Cassette filters are known for their high filtration capacity and efficiency in separation, making them ideal for ultrafiltration, microfiltration, and nanofiltration applications. By integrating these filters into our equipment, we facilitate faster and more effective processes, ensuring high-quality results.
Our equipment, being compatible with Cassette filters, offers greater versatility and adaptability. This means you can choose the filter that best suits your specific needs, ensuring that each experiment or production process is carried out with maximum efficiency and precision.
Moreover, our equipment stands out for its 100% automation capabilities. Utilizing advanced proportional valves, we ensure precise control over differential pressure, transmembrane pressure, and flow rate. This automation not only enhances the efficiency and accuracy of the filtration process but also significantly reduces manual intervention, making our systems highly reliable and user-friendly.
Hollow Fiber
We recognize the crucial role of flexibility and efficiency in laboratory processes. That's why our equipment is meticulously designed to be compatible with Hollow Fiber filters, providing an advanced solution for a broad spectrum of filtration applications. While we don't directly manufacture these filters, our systems are finely tuned to harness the full potential of Hollow Fiber filters.
Hollow Fiber filters are renowned for their exceptional performance in terms of filtration efficiency and capacity. They are particularly effective for applications requiring gentle handling of samples, such as in cell culture and sensitive biomolecular processes. By integrating these filters with our equipment, we enable more efficient, faster, and higher-quality filtration processes.
What sets our equipment apart is its 100% automation capability. Through the use of sophisticated proportional valves, our systems achieve meticulous control over differential pressure, transmembrane pressure, and flow rate. This level of automation not only boosts the efficiency and precision of the filtration process but also significantly diminishes the need for manual oversight, rendering our systems exceptionally reliable and user-friendly.
Defined considering non-hazardous process fluids (PED group 2) and jacket steam/superheated water (PED group 5), depending on configuration and project scope.
| Mode | Element | Working pressure (bar[g]) | Working pressure (psi[g]) | T max (°C / °F) |
|---|---|---|---|---|
| Process | Vessel | 0 / +2.5 | 0 / +36.3 | +90 / 194 |
| Process | Jacket | 0 / +3.8 | 0 / +55.1 | +90 / 194 |
| Sterilisation | Vessel | 0 / +2.5 | 0 / +36.3 | +130 / 266 |
| Sterilisation | Jacket | 0 / +3.8 | 0 / +55.1 | +150 / 302 |
| Working volume | MU (Cell culture), reference | MB (Microbial), reference |
|---|---|---|
| 10 L | 0 to 300 rpm | 0 to 1000 rpm |
| 20 L | 0 to 250 rpm | 0 to 1000 rpm |
| 30 L | 0 to 200 rpm | 0 to 1000 rpm |
| 50 L | 0 to 180 rpm | 0 to 1000 rpm |
The equipment typically includes 4 integrated variable-speed peristaltic pumps for sterile additions (acid/base/antifoam/feeds). Actual flow depends on selected tubing and calibration.
| Parameter | Typical value | Notes |
|---|---|---|
| Quantity | 4 units (integrated) | In control tower; assignment defined by configuration |
| Speed | 0-300 rpm | Variable control from eSCADA |
| Minimum flow | 0-10 mL/min | Example with 0.8 mm ID tubing; depends on tubing and calibration |
| Maximum flow | Up to ~366 mL/min | Example with 4.8 mm ID tubing; actual flow depends on calibration |
| Operating modes | OFF / AUTO / MANUAL / PROFILE | AUTO typically associated to pH/DO/foam loops or recipe |
| Functions | PURGE, calibration, totaliser, PWM | PWM available for low flow setpoints below minimum operating level |
For microbial culture (MB), gas flow controllers (MFC) are typically sized based on VVM targets. Typical reference VVM range: 0.5-1.5 (to be confirmed by process).
| Working volume (L) | VVM min | VVM max | Air (L/min) | O2 (10%) (L/min) | CO2 (20%) (L/min) | N2 (10%) (L/min) |
|---|---|---|---|---|---|---|
| 10 | 0.5 | 1.5 | 5-15 | 0.5-1.5 | 1-3 | 0.5-1.5 |
| 20 | 0.5 | 1.5 | 10-30 | 1-3 | 2-6 | 1-3 |
| 30 | 0.5 | 1.5 | 15-45 | 1.5-4.5 | 3-9 | 1.5-4.5 |
| 50 | 0.5 | 1.5 | 25-75 | 2.5-7.5 | 5-15 | 2.5-7.5 |
Instrumentation is configurable. The following list describes typical sensors integrated in standard configurations, plus common optional PAT sensors.
| Variable / function | Typical technology / interface | Status (STD/OPT) |
|---|---|---|
| Temperature (process/jacket) | Pt100 class A RTD | STD |
| Pressure (vessel/lines) | Pressure transmitter (4-20 mA / digital) | STD |
| Level (working volume) | Adjustable probe | STD |
| pH | Digital pH sensor (ARC or equivalent) | STD |
| DO (pO2) | Digital optical DO sensor (ARC or equivalent) | STD |
| Foam | Conductive/capacitive foam sensor | STD |
| Weight / mass balance | Load cell (integrated in skid) | STD |
| pCO2 | Digital pCO2 sensor (ARC or equivalent) | OPT |
| Biomass (permittivity) | In-line or in-vessel sensor | OPT |
| VCD / TCD | In-situ cell density sensors | OPT (MU) |
| Off-gas (O2/CO2) | Gas analyser for OUR/CER | OPT |
| ORP / Redox | Digital ORP | OPT |
| Glucose / Lactate | PAT sensor | OPT |
The platform incorporates TECNIC eSCADA (typically eSCADA Advanced for ePILOT) to operate actuators and control loops, execute recipes and manage process data.
Support for 21 CFR Part 11 / EU GMP Annex 11 is configuration- and project-dependent and requires customer procedures and validation (CSV).
Utilities depend on final configuration (e.g., AutoSIP vs External SIP) and destination market (EU vs North America). The following values are typical reference points.
| Utility | Typical service / configuration | Pressure | Flow / power | Notes |
|---|---|---|---|---|
| Electrical | EU base: 400 VAC / 50 Hz (3~) | N/A | AutoSIP: 12 kW; External SIP: 5 kW | NA option: 480 VAC / 60 Hz; cabinet/wiring per NEC/NFPA 70; UL/CSA as required |
| Process gases | Air / O2 / CO2 / N2 | Up to 2.5 bar(g) (36.3 psi) | According to setpoint | Typical OD10 pneumatic connections; final list depends on package |
| Instrument air | Pneumatic valves | Up to 6 bar(g) (87.0 psi) | N/A | Dry/filtered air recommended |
| Cooling water | Jacket cooling water | 2 bar(g) (29.0 psi) | 25 L/min (6.6 gpm) | 6-10 °C (43-50 °F) typical |
| Cooling water | Condenser cooling water | 2 bar(g) (29.0 psi) | 1 L/min (0.26 gpm) | 6-10 °C (43-50 °F) typical |
| Steam (External SIP) | Industrial steam | 2-3 bar(g) (29.0-43.5 psi) | 30 kg/h (66 lb/h) | For SIP sequences |
| Steam (External SIP) | Clean steam | 1.5 bar(g) (21.8 psi) | 8 kg/h (18 lb/h) | Depending on plant strategy |
Depending on destination and project scope, the regulatory basis may include European Directives (CE) and/or North American codes. The exact list is confirmed per project and stated in the Declaration(s) of Conformity when applicable.
| Scope | EU (typical references) | North America (typical references) |
|---|---|---|
| Pressure equipment | PED 2014/68/EU | ASME BPVC Section VIII (where applicable) |
| Hygienic design | Hygienic design good practices | ASME BPE (reference for bioprocessing) |
| Machine safety | Machinery: 2006/42/EC (until 13/01/2027) / (EU) 2023/1230 | OSHA expectations; NFPA 79 (industrial machinery) - project dependent |
| Electrical / EMC | LVD 2014/35/EU; EMC 2014/30/EU | NEC/NFPA 70; UL/CSA components and marking as required |
| Materials contact | EC 1935/2004 + EC 2023/2006 (GMP for materials) where applicable | FDA 21 CFR (e.g., 177.2600 for elastomers) - materials compliance |
| Software / CSV | EU GMP Annex 11 (if applicable) | 21 CFR Part 11 (if applicable) |
ePILOT BR is configured per project. To define the right MU/MB package, volumes and options (utilities, sensors, software and compliance), please contact TECNIC with your URS or request the configuration questionnaire.
The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.
The operating range depends on the volume, gas configuration and impeller type. Typical performance references and operating parameters for both applications are summarised below (guideline values; final performance depends on medium, antifoam, geometry and aeration strategy).
Performance and parameters:
Application
Cell culture
Agitation (rpm)
300: 0–450
1000: 0–300
Tip speed (m/s)
0.4–1.8
P/V (W/m³)
80–200
kLa (h⁻¹)
20–30
Application
Microbial
Agitation (rpm)
300: 0–450
1000: 0–300
Tip speed (m/s)
1.5–5.0
P/V (W/m³)
1,000–5,500
kLa (h⁻¹)
150–330
Gas
Process air
Typical range (Ln/min)
300 L: 20–300 (up to 600 depending on configuration)
1000 L: 20–1000 (up to 2000 depending on configuration)
Main use
Aeration by sparger / mixing
Notes by application
Microbial: primary.
Cellular: DO support.
Gas
Oxygen (O₂)
Typical range (Ln/min)
300 L: 2–30 (up to 600 depending on configuration)
1000 L: 2–100 (up to 2000 depending on configuration)
Main use
DO enrichment and cascade
Notes by application
Microbial: frequent. Cellular: cascade at DO set point.
Gas
Carbon dioxide (CO₂)
Typical range (Ln/min)
300 L: 2–30 (typical) / 10–150 (depending on configuration)
1000 L: 2–100 (typical) / 10–500 (depending on configuration)
Main use
pH control / CO₂ balance
Notes by application
Cellular: standard. Microbial: optional.
Gas
Overlay (air or O₂)
Typical range (Ln/min)
300 L: 10–150
1000 L: 10–500
Main use
Headspace scavenging / gas control
Notes by application
Cellular: standard. Microbial: optional.
Note: the exact flow and gas ranges installed depend on the model and the options purchased.
Multi Use Bioreactors
Single Use Bioreactors
Multi Use TFF Systems
Single Use TFF Systems
Single-use bioprocess bags (2D and 3D)
Designed to enhance our bioprocess solutions
Versatile and reliable bioreactor vessels for bioprocessing
Versatile and reliable bioreactor vessels for bioprocessing
